Company intelligence / Profile preview

Lixte Biotechnology Holdings, Inc.

Pasadena, California, United Stateslixte.com ↗

Ownership: Public · LIXT
Employees: ~4
Development stage: Phase 1

Overview

Lixte’s lead compound LB-100, a first-in-class PP2A inhibitor, has demonstrated synergy with both chemotherapy and immunotherapy in preclinical models and early clinical trials. It has shown to be well-tolerated at doses associated with anti-cancer activity. Multiple ongoing Phase I/II studies are evaluating its efficacy in combination regimens for solid tumors such as ovarian clear cell carcinoma, metastatic colon cancer, and advanced soft tissue sarcoma. Early results suggest enhanced treatment outcomes by promoting neoantigen production and T-cell proliferation while disrupting DNA repair in cancer cells

Therapeutic areas: OncologyHematology
Modalities: Small molecules (PP2A inhibitors)
Industry: Biotech

Drug pipeline

1 asset

LB-100

Phase 1

Indications: Ovarian clear cell carcinoma, Colorectal cancer

Partnerships

The University of Texas MD Anderson Cancer CenterNetherlands Cancer InstituteSpanish Sarcoma GroupCollaborations with global pharmaceutical companies for clinical trials of LB‑100

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