Company intelligence / Profile preview
Neutrolis, Inc.
Cambridge, Massachusetts, United Statesneutrolis.com ↗
- Ownership
- Private
- Development stage
- Phase 1
01
Overview
Neutrolis has developed a proprietary enzyme-based approach to dismantle NETs—web-like structures released by overactive neutrophils that drive tissue damage and chronic inflammation in autoimmune and inflammatory disorders. Their lead product NTR‑441, an engineered DNASE1L3 analog, has shown promise as a first-in-class therapy for multiple NET-driven conditions. The company’s pipeline includes programs for lupus, dry eye disease, COVID‑19/ARDS, and other chronic autoimmune conditions. Recent press releases indicate active advancement into the clinic with growing leadership and partnerships[3][4][5].
- Therapeutic areas
- ImmunologyInfectious Diseases
- Modalities
- Engineered enzymes (e.g., DNASE1L3 analogs)Protein therapeutics
- Industry
- Biotech
02
Drug pipeline
4 assets3 more assets in the full pipeline.
03
Partnerships
LabCentral Golden Ticket awards from Pfizer and Bristol Myers Squibblicense agreement with University of Illinois Chicago for dry eye therapy patent[3][5].
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