Original Australian family developers (Kilday and Holmes)

Kilday & Holmes was an Australian family-owned pharmaceutical development firm specializing in topical anesthetic formulations. The company is most notable for the development of Ametop, a 4% tetracaine gel designed for percutaneous local anesthesia. Ametop became a standard of care for reducing pain during needle-related procedures, particularly in pediatric populations, due to its rapid onset compared to earlier alternatives. The company's intellectual property and product rights were eventually acquired by the global medical technology business Smith & Nephew. Today, Kilday & Holmes is recognized for its contribution to improving patient experience in clinical settings through innovative drug delivery.