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ZZ Biotech is developing 3K3A-APC, a genetically engineered variant of activated Protein C. It received FDA Fast Track designation for acute ischemic stroke. Phase 2 trials (RHAPSODY) established maximally tolerated dose; additional Phase 2 trials ongoing for stroke via NIH StrokeNet and ALS. Drug advanced for wound therapies by Dermatherix.[2][7][9]
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