(+)-Menthol

**(+)-Menthol** is a stereoisomer of menthol belonging to the class of menthane monoterpenoids. It is a naturally occurring organic compound found in mint oils and can also be synthesized. While the more common form used medicinally is (-)-menthol (levomenthol), (+)-menthol shares similar physical and chemical properties. Menthol acts primarily as a topical analgesic and counterirritant by activating cold-sensitive Transient receptor potential cation channel subfamily M member 8 (TRPM8) receptors in sensory neurons. This activation produces a cooling sensation and provides relief from minor pain or irritation by modulating neuronal calcium influx and desensitizing pain pathways[7][8][6]. Additional mechanisms may include weak agonism at Kappa-type opioid receptor and modulation of other ion channels such as Voltage-dependent L-type calcium channel[2][6]. The primary indications for menthol compounds are temporary relief of minor aches/pains in muscles/joints or soothing effects on sore throat/irritated mucosa.

Other names

D-menthol(+)-(1S,2R,5S)-menthol(1S,2R,5S)-(+)-menthol(1S,2R,5S)-menthol(+)-(1S,3S,4R)-menthol