Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
(-)-[18F]fluorobenzovesamicol
- Development stage
- Preclinical
- Lead developer
- Université d'Orléans
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
(-)-[18F]fluorobenzovesamicol (also known as (-)-[18F]FBVM) is a radiolabeled vesamicol derivative developed as a positron emission tomography (PET) imaging tracer targeting the vesicular acetylcholine transporter (VAChT). It is designed to visualize and quantify cholinergic terminal density in vivo, which is a key biomarker for assessing cholinergic dysfunction in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and dementia with Lewy bodies. Preclinical studies in rodents have demonstrated that (-)-[18F]fluorobenzovesamicol has a high binding affinity (Ki = 0.9 nM) and selectivity for VAChT, showing a significantly higher striatum-to-cerebellum uptake ratio and superior signal-to-noise ratio compared to other tracers like (-)-[18F]FEOBV.
- Other names
- (-)-(R,R)-5-[18F]fluorobenzovesamicol(-)-5-[18F]fluorobenzovesamicol(-)-5-FBVM(-)-[18F]FBVM(-)[18F]FBVM5-FBVM[18F]FBVMfluorobenzovesamicol
02
Targets
SLC18A3 (Vesicular acetylcholine transporter)
Beyond the preview
Go deeper on (-)-[18F]fluorobenzovesamicol.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on (-)-[18F]fluorobenzovesamicol.