Drug intelligence / Profile preview

(-)-Ampelopsin F

Development stage
Preclinical
Lead developer
CSIR-National Institute for Interdisciplinary Science and Technology
01

Overview

(-)-Ampelopsin F: sourced facts only. name: "Furthermore, AmF effectively inhibited the activity of DPP4, showcasing a 2.5-fold decrease compared to the control and a significant 6.5-fold reduction compared to the positive control." [PMID:38522346]; target: "Furthermore, AmF effectively inhibited the activity of DPP4, showcasing a 2.5-fold decrease compared to the control and a significant 6.5-fold reduction compared to the positive control." [PMID:38522346]; developer: "Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, India." [PMID:38522346]; stage: "The AmF (50 µM) treated cells exhibited a 3.5-fold increase in insulin secretion potential as compared to unstimulated cells, which was achieved through the enhancement of mitochondrial membrane hyperpolarization, elevation of intracellular calcium concentration, and upregulation of GLUT2 and glucokinase expression in pancreatic Beta-TC-6 cell lines." [PMID:38522346]

02

Targets

DPP-4 (Dipeptidyl Peptidase-IV)

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