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(1R)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
(1R)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid is a synthetic small molecule belonging to the class of biphenyls and derivatives. It is an experimental compound that has been studied as a phosphonate-based inhibitor of matrix metalloproteinases (MMPs), particularly MMP8 (neutrophil collagenase). The compound acts by binding to the active site of MMPs and inhibiting their proteolytic activity. This mechanism suggests potential utility in diseases where excessive matrix degradation by MMPs contributes to pathology, such as cancer metastasis or inflammatory conditions[6][7]. However, there are no approved indications or clinical development programs currently associated with this molecule.
- Other names
- ((1R)-1-(4'-methoxy-(1,1'-biphenyl)-4-sulfonamido)-2-methylpropyl)phosphonic acid[(1R)-1-{4'-methoxy-[1,1'-biphenyl]-4-sulfonamido}-2-methylpropyl]phosphonic acid
02
Targets
MMP8 (Neutrophil collagenase)
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