(1R)-2-phenylacetamido-2-(3-carboxyphenyl)ethyl boronic acid

(1R)-2-phenylacetamido-2-(3-carboxyphenyl)ethyl boronic acid is a synthetic small molecule containing a boronic acid moiety. It has been studied as an experimental β-lactamase inhibitor, designed to mimic the transition state of β-lactam hydrolysis and bind to the active site serine of serine β-lactamases. This compound is not approved for clinical use and remains primarily a research tool in enzymology and antibiotic resistance studies[1][5]. Its mechanism involves reversible covalent inhibition of serine β-lactamases by forming a tetrahedral adduct with the catalytic serine residue, thereby blocking enzyme activity.

Other names

3-[(2R)-2-(dihydroxyboranyl)-2-(2-phenylacetamido)ethyl]benzoic acid3-{(2R)-2-(dihydroxyboryl)-2-[(phenylacetyl)amino]ethyl}benzoic acid(R)-3-(2-borono-2-(2-phenylacetamido)ethyl)benzoic acid286940-17-8