(1S,5S,7R)-N~7~-(biphenyl-4-ylmethyl)-N~3~-hydroxy-6,8-dioxa-3-azabicyclo[3.2.1]octane-3,7-dicarboxamide

This compound is a synthetic small molecule belonging to the biphenyl derivatives class with the molecular formula C20H21N3O5 and a molecular weight of approximately 383 g/mol[2][5]. It is an experimental inhibitor of matrix metalloproteinases (MMPs), specifically designed to bind and inhibit several MMP isoforms including MMP12 (macrophage metalloelastase), MMP13 (collagenase 13), MMP10 (stromelysin 2), MMP1 (interstitial collagenase), MMP8 and others involved in extracellular matrix remodeling[5][7]. The mechanism involves chelation of the catalytic zinc ion in the active site of these enzymes via its hydroxamate moiety—a common feature among potent synthetic MMP inhibitors—thereby blocking their proteolytic activity on substrates such as collagen and elastin. The compound has been structurally characterized in complex with human matrix metallopeptidase 12 catalytic domain at high resolution but has not advanced into clinical development or received regulatory approval for any indication as per available data[2][9]. Its primary research use is as a tool compound for studying metalloproteinase inhibition.

Other names

(1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE(1S,5S,7R)-N~7~-(Biphenyl–4–ylmethyl)–N~3~-hydroxy–6,8-dioxa–3–azabicyclo(3.2.1)octane–3,7-dicarboxamide(1S,5S,7R)-N^​_​^​_​(BIPHENYL‑4‑YLMETHYL)‑N^​_​^​_​​HYDROXY‑6⁠8⁠DIOXA⁠−⁠AZABICYCLOOCTANE−37−DICARBOXAMIDE