(2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide

(2E)-N-hydroxy‑3‑[1‑methyl‑4‑(phenylacetyl)‑1H‑pyrrol‑2‑yl]prop‑2-enamide is a synthetic small molecule known as APHA Compound 8. It functions as an inhibitor of histone deacetylases, specifically targeting HDAC enzymes such as HDAC1 and HDAC2, with reported IC50 values in the low nanomolar range. The compound has been studied primarily in biochemical assays and structural biology contexts, including co-crystallization with human HDAC8. There are no known clinical indications or approved uses for this compound; it is used mainly as a research tool to study epigenetic regulation via histone deacetylase inhibition[7][9][10].

Other names

(E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)pyrrol-2-yl]prop-2-enamideN-hydroxy-3-[1-methyl–4-(phenylacetyl)–1H-pyrrol–2–yl]acrylamideN-Hydroxy–3-(1-methyl–4–phenylacetyl–1H-pyrrol–2-yI)acrylamide