(2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine

A synthetic small molecule belonging to the phenylpiperazines class. It is a potent and selective inhibitor of human 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an enzyme involved in glucocorticoid metabolism. The compound was identified through high-throughput screening as part of a series of arysulfonypiperazines and further optimized for potency and selectivity. Its primary research application is as a tool compound for studying the inhibition of 11β-HSD1; it has not been approved or advanced into clinical development for any therapeutic indication[5][1].

Other names

(2R)-1-(4-tert-butylphenyl)sulfonyl-2-methyl-4-(4-nitrophenyl)piperazine(2R)-1-(4-tert-butylbenzenesulfonyl)-2-methyl-4-(4-nitrophenyl)piperazine(R)-1-(4-tert-butylphenylsulfonyl)-2-methyl-4-(4-nitrophenyl)piperazinePiperazine, 1-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2-methyl-4-(4-nitrophenyl)-, (2R)