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(2R,3R,4R,5R)-3,4-dihydroxy-N,N'-bis[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2,5-bis(2-phenylethyl)hexanediamide
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule designed as an experimental inhibitor of the HIV‑1 protease enzyme. It is known as "Diol-Based HIV‑1 protease inhibitor 4" and has been studied for its ability to bind and inhibit the activity of the Gag‑Pol polyprotein dimer (HIV‑1 protease), a critical enzyme required for viral maturation in human immunodeficiency virus type 1 (HIV‑1). The molecule features multiple chiral centers and dihydroxy functional groups that contribute to its binding affinity. Its primary use has been in research settings as a tool compound for understanding structure–activity relationships among non-peptidic HIV protease inhibitors[1][4][6].
- Other names
- (2R,3R,4R,5R)-N,N′-Bis[(1S,2R)-2-hydroxyindan-1-yl]-3,4-dihydroxy–2,5-diphenethylhexanediamide
02
Targets
PR (Progesterone receptor)
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