(2R,4S)-1-(4-butoxyphenyl)sulfonyl-N-hydroxy-4-(methanesulfonamido)pyrrolidine-2-carboxamide

(2R,4S)-1-(4-butoxyphenyl)sulfonyl-N-hydroxy-4-(methanesulfonamido)pyrrolidine-2-carboxamide is a synthetic small molecule identified as a potent inhibitor of Matrix Metalloproteinase 3 (MMP3). It belongs to the class of hydroxamate-based MMP inhibitors, which typically function by chelating the catalytic zinc ion in the active site of MMP enzymes. The compound's interaction with MMP3 has been characterized through X-ray diffraction studies, as evidenced by its presence in the Protein Data Bank (PDB entry 1G49) in complex with MMP3. While specific therapeutic indications or development status for this exact compound are not widely detailed in public databases, MMP inhibitors have historically been investigated for various conditions involving tissue remodeling and inflammation, such as arthritis and cancer.

Other names

(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-PyrrolidineRefChem:392763CHEMBL358064CHEMBL-358064CHEMBL 3580641g49BDBM50095567BDBM-50095567BDBM 50095567DB02367DB-02367DB 02367PD008007PD-008007PD 008007NS00069426NS-00069426NS 00069426Q27093377Q-27093377Q 27093377(4S)-1-[(4-butoxyphenyl)sulfonyl]-N-hydroxy-4-[(methylsulfonyl)amino]-D-prolinamide1-(4-Butoxy-benzenesulfonyl)-4-methanesulfonylamino-pyrrolidine-2-carboxylic acid hydroxyamide