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(2s)-2-[(2,4-dichloro-benzoyl)-(3-trifluoromethyl-benzyl)-amino]-3-phenyl-propionic acid
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule derivative of phenylalanine featuring a 2,4-dichlorobenzoyl group and a 3-trifluoromethylbenzyl group attached to the amino functionality. It has been studied as an experimental inhibitor of the Hepatitis C virus NS5B RNA-dependent RNA polymerase. The mechanism involves non-nucleoside inhibition by binding to an allosteric site on the viral polymerase, thereby blocking viral RNA synthesis. The compound is not approved for clinical use and remains primarily a research tool in structural biology and antiviral drug discovery[1][5][7].
- Other names
- N-(2,4-dichlorobenzoyl)-N-[3-(trifluoromethyl)benzyl]-L-phenylalanine(2S)-2-[1-(2,4-dichlorophenyl)-N-{[3-(trifluoromethyl)phenyl]methyl}formamido]-3-phenylpropanoic acid
02
Targets
NS5B (Hepatitis C virus non-structural protein 5B (NS5B) RNA-dependent RNA polymerase)
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