(2S)-4-(2,5-difluorophenyl)-N-methyl-2-phenyl-N-piperidin-4-yl-2,5-dihydro-1H-pyrrole-1-carboxamide

This compound is a synthetic small molecule belonging to the phenylpyrroline class. It has been studied as an inhibitor of kinesin spindle protein (KSP), a mitotic kinesin essential for cell division. KSP inhibitors are being explored as potential anticancer agents due to their ability to disrupt mitosis in rapidly dividing tumor cells. The compound was developed during efforts to optimize KSP inhibition while minimizing off-target effects such as hERG channel binding and P-glycoprotein-mediated efflux. While related analogs have advanced into clinical trials (e.g., MK‐0731), this specific molecule is primarily referenced in medicinal chemistry literature and chemical databases as an experimental or tool compound[6][7].

Other names

dihydropyrrole, 13