(2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amine

This compound is a synthetic small molecule with the chemical formula C21H25ClFN3O3S and a molecular weight of approximately 454 Da[1][5][7]. It features a polycyclic aromatic structure containing both benzene and 1,2,4‑oxadiazole rings. The compound was developed as part of research into dipeptidyl peptidase IV (DPP‑IV or DPP‑4) inhibitors—a class of drugs that modulate glucose metabolism by inhibiting the enzyme DPP‑IV. This mechanism is relevant for potential antidiabetic therapies. The compound has been described in medicinal chemistry literature as a potent fluoroolefin-derived DPP‑IV inhibitor but has not advanced beyond preclinical or early experimental stages[8]. There are no approved indications or clinical trials reported for this molecule.

Other names

(2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amine317 (RCSB PDB ligand code)