(2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide

(2Z)-N-biphenyl–4–yl–2–cyano–3–hydroxybut–2–enamide is a synthetic small molecule belonging to the biphenyl derivatives class, with the molecular formula C17H14N2O2 and a molecular weight of approximately 278.31 g/mol. It is primarily referenced as an experimental compound in chemical and structural biology databases, including DrugBank (DB07443), PubChem (CID 54727972), and RCSB PDB ligand BCE[1][6][8]. The compound has not been approved for any therapeutic use or entered clinical trials beyond preclinical research phases. Its mechanism of action is not explicitly described in public sources; however, its code name "hDHODH-IN‑1" suggests it may act as an inhibitor of human dihydroorotate dehydrogenase (hDHODH), an enzyme involved in pyrimidine biosynthesis—a target relevant to immunomodulation and oncology research. No information on specific indications, developers, or manufacturers is available.

Other names

(Z)-2-cyano-3-hydroxy-N-(4-phenylphenyl)but-2-enamideN-{[1,1'-biphenyl]-4-yl}-2-cyano-3-hydroxybut-2-enamide1173715–42–8BCE