(2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime}

This compound is a synthetic small molecule belonging to the class of indolines and biindoles. It is structurally related to indirubin derivatives and has been studied primarily as a kinase inhibitor in structural biology research. The molecule has been co-crystallized with several protein kinases in the Protein Data Bank (PDB), including human calcium/calmodulin-dependent protein kinase type II alpha (CAMK2A) and PCTAIRE1 kinase. Its mechanism of action involves binding to the ATP-binding pocket of kinases as an inhibitor; however, it is not an approved pharmaceutical drug and remains experimental with no established clinical indications[1][4][7][10].

Other names

(Z,3E)-3-{[(3R)-3,4-dihydroxybutoxy]imino}-1',2'-dihydro-1H,3H-[2,3'-biindolyliden]-2'-one