(3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime

This compound is a synthetic small molecule belonging to the class of benzo[1,3]dioxanes and isatin oximes. It was developed as part of a series of N-benzylated isatin oximes designed to selectively inhibit c-Jun N-terminal kinase 3 (JNK3), a member of the mitogen activated protein kinase family. JNKs are implicated in neurodegenerative diseases and other pathologies involving stress signaling pathways. Structural studies have shown that this compound binds to JNK3 but not p38 MAP kinase, providing selectivity insights for this chemotype. The compound has been studied primarily in preclinical research settings and does not have an assigned brand name or clinical indication[1][8][9].

Other names

(3Z)-1-[(6-fluoro-2,4-dihydro-1,3-benzodioxin-8-yl)methyl]-3-(hydroxyimino)-4-phenylindol-2-one(3Z)-1-[6-fluoro-benzo[d][1,3]dioxin–8–yl)methyl]-4–phenyl–indole–2,3-dione 3–oximeDB08015DB-08015DB 08015