(4e)-4-aminohex-4-enoic acid

(4e)-4-Aminohex-4-Enoic Acid is a synthetic gamma amino acid derivative with the molecular formula C6H11NO2 and a molecular weight of approximately 129.16 g/mol[1][2][8]. It is classified as an experimental small molecule compound and has not been approved for clinical use in any country[1]. The compound acts as an inhibitor of the enzyme 4‑aminobutyrate aminotransferase, mitochondrial (also known as GABA transaminase or GABA-T), which plays a key role in the catabolism of gamma‑aminobutyric acid (GABA), an important inhibitory neurotransmitter in the central nervous system[3][7]. By inhibiting this enzyme, compounds like (4e)-4-Aminohex‑4‑Enoic Acid can potentially increase brain GABA levels. This mechanism is similar to that of certain antiepileptic drugs targeting GABA metabolism, though there are no indications that this specific compound has advanced beyond experimental status or entered clinical trials for epilepsy or other neurological disorders[1][3].

Other names

(E)-4-aminohex-4-enoic acid*E*)-4-aminohex-4-enoic acid4-Hexenoic acid, 4-amino-, (4E)-GEG