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(4S,5R)-3-(N-benzoyl)-2-paramethoxyphenyl-4-phenyl-oxazolidine-5-carboxylic acid
- Development stage
- Preclinical
- Lead developer
- XinKe
- Modality
- Small Molecules
01
Overview
(4S,5R)-3-(N-benzoyl)-2-paramethoxyphenyl-4-phenyl-oxazolidine-5-carboxylic acid is a small molecule chemical intermediate developed by XinKe for the semi-synthesis of the chemotherapy drug paclitaxel. This oxazolidine-protected derivative serves as the precursor for the essential phenylisoserine side chain of paclitaxel, which is required for its ability to bind to and stabilize microtubules. By providing a stereochemically pure building block, this intermediate facilitates the efficient production of taxane-based antineoplastic agents. While primarily used in manufacturing, it is associated with the development of treatments for various cancers, including breast, ovarian, and lung cancer, where paclitaxel is a standard of care.
- Other names
- (4S,5R)-3-(N-benzoyl)-2-paramethoxyphenyl-4-phenyl-oxazolidine-5-carboxylic acidPaclitaxel side-chain intermediate(4S,5R)-3-benzoyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid
02
Targets
TUBB (Tubulin (alpha and beta subunits))SRC (Proto-oncogene tyrosine-protein kinase Src)
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