(4s-Trans)-4-(Methylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-Dioxide

This compound is a synthetic small molecule belonging to the thieno-thiopyran sulfonamide class. It is structurally related to dorzolamide and acts as a potent inhibitor of carbonic anhydrase 2. The drug has been studied primarily in experimental settings and has not received regulatory approval for any indication. Its primary mechanism involves inhibition of the enzyme carbonic anhydrase 2 with high affinity (Ki ≈ 1.9 nM), suggesting potential utility in conditions where modulation of this enzyme is beneficial—such as glaucoma or other disorders involving intraocular pressure—but it has not advanced beyond preclinical or early research phases[2][3][5].

Other names

(4S,6S)-6-Methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxideMTS