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(5E)-12-chloro-13,15-dihydroxy-4,7,8,9-tetrahydro-2-benzoxacyclotridecine-1,10(3H,11H)-dione
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule belonging to the class of hydroxybenzoic acid derivatives. It is structurally related to radicicol analogues and has been studied as a ligand for the ATP-binding site of heat shock protein 90 (Hsp90), specifically in yeast Hsp82 and human HSP90AB1. By binding to this chaperone protein's ATP-binding domain—an essential region for its function—the compound acts as an inhibitor of Hsp90 activity. Inhibition of Hsp90 can disrupt the folding and stability of multiple client proteins involved in cell growth and survival pathways. This mechanism is relevant in cancer research where Hsp90 inhibitors are explored as potential antineoplastic agents[1][4][8].
- Other names
- (5e)-12-chloro-13,15-dihydroxy-4,7,8,9-tetrahydro-2-benzoxacyclotridecine-1,10(3h,11h)-dioneMicrolactone 15f transMicrolactone15f transMicrolactone-15f trans
02
Targets
HSP90AB1 (Heat shock protein HSP 90-beta)
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