(5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one

This compound is a synthetic small molecule inhibitor of the enzyme 11-beta-hydroxysteroid dehydrogenase 1 (11β-HSD1). It has been studied as an experimental agent for modulating glucocorticoid metabolism by inhibiting the conversion of cortisone to cortisol. The compound demonstrates potent inhibition of human recombinant 11β-HSD1 with a reported Ki value of approximately 22 nM. There are no approved indications or clinical trials in advanced phases for this molecule; it remains an experimental research tool and has not reached clinical development or regulatory approval[2][4]. The structure contains both fluorinated aromatic and thiazolone moieties.

Other names

(S)-2-((S)-1-(2-fluorophenyl)ethylamino)-5-methyl-5-(trifluoromethyl)thiazol-4(5H)-one4(5H)-Thiazolone, 2-[[(1S)-1-(2-fluorophenyl)ethyl]amino]-5-methyl-5-(trifluoromethyl)-, (5S)