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(5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N-ethyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide
- Development stage
- Preclinical
- Lead developer
- Merck
- Modality
- Small Molecules
01
Overview
This compound is a small molecule belonging to the phenylpyrazole class. It was developed as a potent and water-soluble inhibitor of the mitotic kinesin spindle protein KIF11 (also known as Eg5 or kinesin-like protein KSP), which is essential for establishing bipolar spindles during cell division. Inhibition of KIF11 leads to mitotic arrest with monoastral microtubule arrays and prevents centrosome migration. The compound was designed using structure-based drug design strategies to improve potency and solubility over earlier inhibitors. Its primary research focus has been in oncology as an anti-mitotic agent targeting cancer cell proliferation[2][6].
- Other names
- (5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE
02
Targets
KIF11 (Kinesin Spindle Protein)
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