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(5Z)-3-(4-chlorophenyl)-4-hydroxy-5-(1-naphthylmethylene)furan-2(5H)-one
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule belonging to the naphthalenes class, specifically a naphthyl tetronic acid derivative. It has been studied as an experimental inhibitor of the bacterial enzyme UDP-N-acetylenolpyruvoylglucosamine reductase (MurB), which is essential for peptidoglycan biosynthesis in bacteria. By inhibiting MurB, it disrupts cell wall synthesis and exhibits antibacterial activity, particularly against Gram-negative pathogens such as Escherichia coli and Acinetobacter baumannii. The compound has demonstrated binding to the active site of MurB in structural studies and computational docking analyses[6][7]. Its primary use is as a research tool or lead compound for developing new antibiotics targeting resistant bacterial infections.
- Other names
- (5Z)-3-(4-chlorophenyl)-4-hydroxy-5-(1-naphthylmethylene)furan-2(5H)-one(5Z)-3-(4-chlorophenyl)-4-hydroxy-5-(naphthalen-1-ylmethylidene)furan-2-one
02
Targets
MurB (UDP-N-acetylenolpyruvoylglucosamine reductase)
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