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(R)-(+)9B-(3-methyl)phenyl-2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-one
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
(R)-(+)9B-(3-methyl)phenyl-2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-one is a synthetic small molecule belonging to the isoindolone class of organic compounds. It has been studied as a non-nucleoside reverse transcriptase inhibitor (NNRTI), specifically targeting HIV‑1 reverse transcriptase. Structural studies have shown it binds to the allosteric NNRTI binding pocket of HIV‑1 reverse transcriptase and inhibits its activity by inducing conformational changes that prevent viral DNA synthesis. The compound is primarily used in research settings and has not been approved for clinical use.[1][2][7][10]
- Other names
- (R)-(+)9B-(3-METHYL)PHENYL-2,3-DIHYDROTHIAZOLO[2,3-A]ISOINDOL-5(9BH)-ONE(9bR)-9b-(3-methylphenyl)-2H,3H,5H,9bH-[1,3]thiazolo[2,3-a]isoindol-5-one(+)-(R)-9b-(3-methylphenyl)-2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-one
02
Targets
Human immunodeficiency virus type 1 reverse transcriptase
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