Drug intelligence / Profile preview

(R)-1,3-butanediol

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

(R)-1,3-butanediol is a chiral secondary alcohol with two hydroxyl groups (diol) that serves as an endogenous metabolite and research compound[3][8]. The (R)-enantiomer undergoes stereospecific metabolism to β-hydroxybutyrate via alcohol dehydrogenase through zinc-dependent pathways, maintaining cellular redox balance[3]. It has been investigated for its potential to regulate carbohydrate and lipid metabolism[4] and induce mild euphoric effects through ketone body signaling pathways distinct from ethanol's GABAergic mechanisms[3]. The compound is colorless, odorless, and water-soluble with a slightly sweet taste and bitter aftertaste[2][3].

Other names
(R)-1,3-butylene glycol(R)-butane-1,3-diol(R)-1,3-dihydroxybutane
02

Targets

ADH (Alcohol dehydrogenase family)

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