(R)-2-(6,8-Dibromo-2-oxo-2H-chromene-3-carboxamido)-5-(ethylamino)-5-oxopentanoic Ethyl Ester

DTBrC, or (R)-2-(6,8-Dibromo-2-oxo-2H-chromene-3-carboxamido)-5-(ethylamino)-5-oxopentanoic Ethyl Ester, is a semisynthesized derivative of theanine. It is being investigated for its anticancer activities, particularly in human hepatocellular carcinoma (HHC). DTBrC has demonstrated inhibitory effects on the growth and migration of HHC cells in various models (in vitro, ex vivo, and in vivo). It also enhances the repression of HHC cell growth when combined with the anticancer drug pirarubicin. Its mechanism of action involves repressing the protein expressions in the Met/EGFR/VEGFR-Akt/NF-κB signaling pathways and enhancing p53 protein expression.