Drug intelligence / Profile preview

(r)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol

Development stage
Unknown
Lead developer
UCB
Modality
Small Molecules
01

Overview

(R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol is a small molecule belonging to the class of phenol ethers, which are aromatic compounds containing an ether group substituted with a benzene ring. It has been studied as a fragment in structure-based drug discovery, particularly in the context of leukotriene A₄ hydrolase (LTA₄H) inhibition. The compound was identified as part of a fragment library used to interrogate protein active sites and allosteric binding sites for fragment binding, and it was found to bind LTA₄H by X-ray crystallography. However, there is no evidence of clinical development or approval for any indication[5][6][7].

Other names
(R)-4-Pyridinyl{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}methanol(R)-pyridin-4-yl({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl})methanolpyridin-4-yl-[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol80A
02

Targets

LTA4H (Leukotriene A4 hydrolase)

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