(S)-3,4-dicarboxyphenylglycine

**(S)-3,4-dicarboxyphenylglycine (DCPG)** is a synthetic small molecule used in scientific research as a potent, highly selective agonist for the metabotropic glutamate receptor 8 (mGluR8)[2][5][9][10]. DCPG demonstrates over 100-fold selectivity for mGluR8 compared to other metabotropic glutamate receptors and displays little or no activity on NMDA and kainate receptors[5]. Its primary research applications include studies of anticonvulsant effects and hyperalgesia models, with emerging investigation around its effects on addiction pathways and modulation of reward in animal models[2][8].

Other names

(S)-3,4-Dicarboxyphenylglycine201730-11-24-[(1S)-1-amino-2-hydroxy-2-oxoethyl]phthalic acid4-((1S)-1-amino-2-hydroxy-2-oxoethyl)phthalic acid