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(S)-4,5-dihydroxy-2,3-pentanedione
- Development stage
- Preclinical
- Lead developer
- OMM Scientific
- Modality
- Small Molecules
- Administration
- Intranasal, Intravenous, Oral, Subcutaneous, Intramuscular, Topical, Transdermal, Rectal, Sublingual
01
Overview
(S)-4,5-dihydroxy-2,3-pentanedione (DPD) is a small molecule that serves as the essential precursor to Autoinducer-2 (AI-2), a universal signaling molecule used by both Gram-positive and Gram-negative bacteria for interspecies quorum sensing. Developed and supplied by OMM Scientific, DPD is primarily utilized as a research reagent to investigate bacterial communication mechanisms, including the regulation of biofilm formation, virulence factor expression, and motility. In aqueous solution, DPD exists in a dynamic equilibrium of linear and cyclic forms, which are recognized by specific bacterial receptors such as LuxP or LsrB. Beyond its role as a laboratory tool, DPD has been explored for potential therapeutic applications, including serving as a vaccine adjuvant or as a target for modulating bacterial infections by disrupting quorum sensing pathways.
- Other names
- AI-2AI2AI 2Autoinducer-2Autoinducer2Autoinducer 2(S)-DPD
02
Targets
LsrR (LsrR transcriptional repressor)LsrK (Autoinducer-2 kinase)
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