(S)-alpha-methyl-4-carboxyphenylglycine

(S)-alpha-methyl-4-carboxyphenylglycine is a non-proteinogenic alpha-amino acid and a synthetic analog of alanine, where the alpha-hydrogen is replaced by a 4-carboxyphenyl group. It acts as a non-selective antagonist of group I and group II metabotropic glutamate receptors (mGluRs), thereby inhibiting glutamatergic neurotransmission mediated by these receptor subtypes. This compound is primarily used in research to study the physiological roles of mGluRs in the central nervous system[1][10]. It does not have established therapeutic indications or approved pharmaceutical uses.

Other names

4-[(1S)-1-amino-1-carboxyethyl]benzoic acid(+)-alpha-methyl-4-carboxyphenylglycineS(+)-alpha-amino-4-carboxy-alpha-methyl-benzeneacetic acidalpha-methyl-2-(4-carboxyphenyl)-L-glycine