(S)-camphor

(S)-camphor is a stereoisomer of camphor—a bicyclic monoterpene ketone primarily isolated from the wood of the camphor laurel tree (Cinnamomum camphora). It has a long history of medicinal use as a topical analgesic and antipruritic agent and is an active ingredient in many over-the-counter balms and liniments for minor muscle and joint pain relief. Camphor acts by exciting and desensitizing sensory nerves through activation of heat-sensitive TRP vanilloid subtype 1 (TRPV1) and TRPV3 receptors; it also inhibits TRPA1 channels. These actions produce sensations of warmth or coolness that underlie its counterirritant effects. The (S) stereoisomer displays similar but somewhat weaker activity on these channels compared to other forms[1][5][6][8]. Camphor is FDA-approved for topical use as an analgesic, anesthetic, antitussive (anti-cough), anti-itch agent, and for symptom relief in osteoarthritis[2].

Brand names

cemphire

Other names

camphorCinnamomum camphora(-)-camphorS-4(S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one