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(S)-lacosamide
- Development stage
- Preclinical
- Lead developer
- UCB
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
(S)-lacosamide is a small molecule drug that is an inactive analog of the clinically approved anti-epileptic drug (R)-Lacosamide (Vimpat®). Despite being an inactive analog of (R)-Lacosamide, (S)-lacosamide exhibits a distinct mechanism of action relevant to migraine treatment. It inhibits the phosphorylation of collapsin response mediator protein 2 (CRMP2) by cyclin dependent kinase 5 (Cdk5) in sensory neurons. This action leads to a decrease in depolarization-evoked Ca2+ influx and subsequently blocks the release of calcitonin gene related peptide (CGRP) from dural nerve terminals. (S)-lacosamide has shown potential as a therapy for acute migraine by inhibiting cutaneous allodynia in animal models.
- Other names
- (S)-LCM
02
Targets
CRMP2 (Collapsin response mediator protein 2)CDK5 (Cyclin-dependent kinase 5)CACNA1B (Voltage-dependent N-type calcium channel subunit alpha-1B)
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