(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide

(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide is an experimental small molecule inhibitor designed to target serine proteases, particularly trypsin-like serine protease 1 (PRSS1). It is a synthetic peptidomimetic compound containing a benzamidine moiety, which is known for its ability to inhibit serine proteases by mimicking the transition state of peptide substrates. The compound has been studied in structural biology as a selective inhibitor and probe for understanding the binding and inhibition of trypsin-like enzymes. Its primary mechanism involves competitive inhibition at the active site of these enzymes, preventing substrate cleavage[1][3][10]. There are no approved clinical indications or marketed formulations.

Other names

49U (PDB ligand code)