Drug intelligence / Profile preview

[111In]In-3p-C-NETA-PSMA

Development stage
Preclinical
Lead developer
Erasmus MC
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Gamma Emitters → Radiopharmaceuticals, Small Molecules
Administration
Intravenous
01

Overview

[111In]In-3p-C-NETA-PSMA (also known as [111In]In-3p-C-NETA-ePSMA-16) is a diagnostic radiopharmaceutical designed for the imaging of prostate cancer. It consists of a prostate-specific membrane antigen (PSMA)-targeting ligand (Lys-urea-Glu) conjugated to the bifunctional chelator 3p-C-NETA, which is radiolabeled with the gamma-emitting isotope indium-111 (111In). The agent is designed for single-photon emission computed tomography (SPECT) imaging to detect PSMA-expressing prostate cancer cells and estimate personalized dosimetry for subsequent radionuclide therapy. It was developed through a collaboration involving Erasmus MC and KU Leuven.

Other names
111In-3p-C-NETA-PSMA111In-3p-C-NETA-ePSMA-163p-C-NETA-PSMA3p-C-NETA-ePSMA-16[111In]In-3p-C-NETA-ePSMA-16indium-111 3p-C-NETA-PSMAindium111 3p-C-NETA-PSMAindium 111 3p-C-NETA-PSMAindium-111 3p-C-NETA-ePSMA-16indium111 3p-C-NETA-ePSMA-16indium 111 3p-C-NETA-ePSMA-16
02

Targets

PSMA (Prostate-specific membrane antigen)

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