[11C]BU99008

[11C]BU99008 is a radiolabeled positron emission tomography (PET) ligand specifically developed for imaging imidazoline2 binding sites (I2BS) in the brain. I2BS are believed to be expressed predominantly in glial cells and are implicated in the regulation of glial fibrillary acidic protein, with potential roles in neurodegenerative and neuroinflammatory diseases. [11C]BU99008 demonstrates high affinity and selectivity for I2BS, with minimal off-target binding to monoamine oxidase (MAO). It exhibits good brain penetration, reversible kinetics, heterogeneous distribution consistent with known I2BS expression patterns, and reliable test-retest reproducibility. The compound is used as a diagnostic radiopharmaceutical tool for research purposes to investigate alterations of I2BS expression in various neurological conditions[1][2][3][5].

Other names

Carbon-11 BU99008Carbon11 BU99008Carbon 11 BU9900811C-BU99008