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[11C]CHDI-00485180-R

Development stage: Unknown
Lead developer: CHDI Foundation
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

[11C]CHDI-00485180-R is a Carbon-11 labeled radiopharmaceutical developed as a positron emission tomography (PET) tracer specifically designed to bind to mutant Huntingtin (mHTT) protein aggregates. Developed by the CHDI Foundation, this small molecule tracer is intended for use in clinical research to non-invasively quantify the burden and distribution of mHTT in the brains of individuals with Huntington's disease. By providing a direct measure of the pathological protein, [11C]CHDI-00485180-R serves as a critical biomarker for monitoring disease progression and evaluating the pharmacodynamic effects of huntingtin-lowering therapeutic candidates in clinical trials.

Other names: [11C]CHDI-485180-R

Targets

HTT (Huntingtin protein)

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