[11C]DPA-713

[11C]DPA-713 is a radiolabeled small molecule used as a positron emission tomography (PET) imaging agent. It is a selective ligand for the translocator protein (TSPO), formerly known as the peripheral benzodiazepine receptor, which is upregulated in activated microglia and other cells during neuroinflammation. By binding to TSPO, [11C]DPA-713 enables noninvasive visualization and quantification of neuroinflammatory processes in vivo. Compared to earlier TSPO PET tracers such as [11C](R)-PK11195, [11C]DPA-713 demonstrates higher specific binding, improved signal-to-noise ratio due to lower nonspecific binding, and greater sensitivity for detecting increased TSPO expression in both preclinical models and human studies. It has been evaluated for use in various neurological conditions associated with neuroinflammation including epilepsy, schizophrenia, bipolar disorder, ischemic stroke models in animals, and Gulf War Illness[1][2][3][4][5][6][7].

Other names

DPA-713DPA713DPA 713N,N-diethyl-2-(4-methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide