[123I]-CNS 1261

[123I]-CNS 1261 is a radiolabeled ligand used as a SPECT (Single Photon Emission Computed Tomography) imaging agent for the NMDA (N-methyl-D-aspartate) receptor, specifically binding to the MK801 intrachannel site. It is primarily utilized in research settings to study glutamatergic neurotransmission and NMDA receptor function in the human brain. The tracer allows for non-invasive quantification of NMDA receptor availability and has been investigated in neuropsychiatric disorders such as schizophrenia. Studies have shown that global binding of [123I]-CNS 1261 can be altered by antipsychotic treatment, indicating its potential utility in monitoring disease state or drug effects on glutamatergic systems[1][3][4].

Other names

[(123)I]CNS 1261[123I] CNS-1261Iodine-123 CNS-1261Iodine123 CNS-1261Iodine 123 CNS-1261