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[177Lu]Lu-XT117

Development stage: Unknown
Lead developer: Sinotau Pharmaceutical Group
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

[177Lu]Lu-XT117 is a next-generation radiopharmaceutical therapy consisting of the beta-emitting radioisotope lutetium-177 conjugated to XT117, a fibroblast activation protein (FAP) antagonist. Developed initially by Sinotau Pharmaceutical Group, XT117 is designed to target FAP, which is highly expressed in the tumor stroma of various advanced solid tumors. The drug aims to deliver targeted cytotoxic radiation to the tumor microenvironment, leveraging the high affinity and prolonged intratumoral retention of the XT117 ligand. It is currently being evaluated in Phase 1 clinical trials for safety, dosimetry, and preliminary efficacy in patients with FAP-positive advanced solid tumors refractory to standard therapies.

Other names: [177Lu]Lu-XT117 injection177Lu-XT117

Targets

FAP (Fibroblast activation protein alpha)

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