Drug intelligence / Profile preview

[177Lu]Lu-XT381

Development stage: Unknown
Lead developer: Sinotau Pharmaceutical Group
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

[177Lu]Lu-XT381 is a Lutetium-177 labeled radioligand therapy targeting the prostate-specific membrane antigen (PSMA). Developed by Sinotau Pharmaceutical Group (Beijing Xiantong International Pharmaceutical Technology), it is designed for the treatment of PSMA-positive metastatic castration-resistant prostate cancer (mCRPC). The drug consists of a PSMA-targeting ligand (XT381) conjugated to the beta-emitting radioisotope Lutetium-177. Upon binding to PSMA-expressing tumor cells, the compound is internalized, delivering localized ionizing radiation that induces DNA damage and cell death. It is currently being evaluated in Phase Ib/II clinical trials in China for patients who have progressed on next-generation androgen receptor-directed therapies.

Other names: Lu-177 XT381Lu177 XT381Lu 177 XT381177Lu-XT381

Targets

PSMA (Prostate-specific membrane antigen)

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