Drug intelligence / Profile preview

[18F]-SKI-249380

Development stage: Unknown
Lead developer: Memorial Sloan Kettering Cancer Center
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

[18F]-SKI-249380 is a diagnostic radiopharmaceutical and a positron emission tomography (PET) tracer. It is a radiolabeled analog of the multi-targeted tyrosine kinase inhibitor dasatinib. This tracer is designed for imaging the in vivo pharmacokinetics of dasatinib and for detecting tumors in patients by visualizing the binding to dasatinib's molecular targets. It allows for non-invasive characterization of dasatinib pharmacokinetics in tumors and organs.

Other names: [18F]-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-fluoroethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide

Targets

PDGFR (PDGFR family)KIT (c-KIT proto-oncogene receptor tyrosine kinase)ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)

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