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[18F]1
- Development stage
- Preclinical
- Lead developer
- Emory University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
[18F]1 is a fluorine-18 labeled positron emission tomography (PET) radiotracer developed for the noninvasive imaging and quantitative assessment of vasopressin 1A (V1A) receptor expression in vivo. Developed by researchers at Emory University, [18F]1 exhibits high nanomolar affinity for the human V1A receptor (IC50 of 0.64 nM) and demonstrates favorable in vitro and in vivo stability. Preclinical evaluation in rodents and non-human primates has shown pronounced hepatic uptake and specific V1A-mediated binding, suggesting its potential utility in assessing V1A receptor involvement in hepatic, cardiovascular, and neuropsychiatric disorders.
- Other names
- [18F]compound 1compound 1compound1compound-1
02
Targets
AVPR1A (Arginine vasopressin receptor 1A)
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