[18F]15

[18F]15 is a fluorine-18 labeled radiopharmaceutical developed as a positron emission tomography (PET) radiotracer targeting the receptor tyrosine kinase EphB4. It is based on a benzodioxolylpyrimidine structural motif derived from potent inhibitors of the EphB4 kinase domain. EphB4 is a member of the Eph receptor family that plays a significant role in cancer progression, angiogenesis, and metastasis, particularly in malignant melanoma. While the non-radioactive reference compound demonstrates potent inhibition of both EphB4 and Src kinase, preclinical radiopharmacological evaluations of [18F]15 in mouse models have shown high metabolic stability but limited accumulation in EphB4-overexpressing tumors. Consequently, it serves primarily as a lead structure for the development of more effective radiotracers for imaging Eph receptor tyrosine kinases in oncology.

Other names

18F-labeled benzodioxolylpyrimidinefluorine-18 labeled EphB4 inhibitorfluorine18 labeled EphB4 inhibitorfluorine 18 labeled EphB4 inhibitor