[18F]BCPP-EF

[18F]BCPP-EF is a fluorine-18 radiolabeled small molecule PET radiotracer designed to selectively bind to mitochondrial complex I (MC-I), also known as NADH-ubiquinone oxidoreductase. MC-I is the first and rate-limiting enzyme of the mitochondrial electron transport chain, making it a critical marker for mitochondrial density and function. Originally developed by researchers in Japan (associated with Hamamatsu Photonics), the tracer is used as a diagnostic imaging tool to evaluate brain energy metabolism and mitochondrial activity. It is currently being investigated in early-phase clinical studies for neurodegenerative conditions such as Parkinson's disease and Friedreich's ataxia, as well as for assessing brain mitochondrial activity in individuals with cocaine use disorder.

Other names

2-tert-butyl-4-chloro-5-{6-[2-(2[18F]fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2H-pyridazin-3-one[F-18]BCPP-EF