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Drug intelligence / Profile preview
[18F]CHL2310
- Development stage
- Unknown
- Lead developer
- Emory University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals
01
Overview
[18F]CHL2310: sourced facts only. name: "CHL2310 was identified as a potent inhibitor of CYP46A1 and subsequently labeled with fluorine-18 in a radiochemical yield of 13% and a high molar activity of 93 GBq/μmol." [PMID:40109739]; target: "CHL2310 was identified as a potent inhibitor of CYP46A1 and subsequently labeled with fluorine-18 in a radiochemical yield of 13% and a high molar activity of 93 GBq/μmol." [PMID:40109739]; developer: "Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States." [PMID:40109739]; modality: "This study presents the synthesis and evaluation of [18F]5 ([18F]CHL2310) as a novel radioligand for imaging CYP46A1 and cholesterol metabolism in the brain by positron emission tomography (PET)." [PMID:40109739]
02
Targets
CYP46A1 (Cholesterol 24-hydroxylase)
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