[18F]DPA-714 + [18F]AV-45

This is a combination of two radiopharmaceutical PET imaging agents: **[18F]DPA‑714** and **[18F]AV‑45**. **[18F]DPA‑714** is a selective ligand for the translocator protein (TSPO), which is upregulated in activated microglia during neuroinflammation. It enables visualization and quantification of neuroinflammatory processes in the brain using positron emission tomography (PET). It has been studied for imaging conditions such as glioma, rheumatoid arthritis, multiple sclerosis, Alzheimer's disease, epilepsy, stroke, and schizophrenia by targeting TSPO expression associated with inflammation or pathology[1][2][3][4][5]. **[18F]AV‑45**, also known as florbetapir F 18 (not detailed in search results but widely known), is a PET tracer that binds to beta amyloid plaques in the brain and is used primarily for imaging amyloid deposition in Alzheimer's disease. The combination allows simultaneous or sequential assessment of both neuroinflammation ([18F]DPA‑714/TSPO) and amyloid plaque burden ([18F]AV‑45/amyloid-beta), providing complementary information about different pathological processes relevant to neurodegenerative diseases.